Nanotechnology

Week 10 - Nanobiotechnology

Of all the emerging areas in nanotechnology, nanobiotechnology, and bionanotechnology, are the ones where we are making advances and commercialization the fastest. Also, the upcoming filed of synthetic biology offers real hope for 'molecular nanotechnology'.

Nano-Bio-Info convergence - http://www.nanobioconvergence.org/index.aspx
DNA microarrays
- GeneChip(TM), SNP, and protein arrays - http://www.gene-chips.com
- Functional Genomics Resources - http://www.sciencemag.org/feature/plus/sfg/resources/res_expression.shtml
Self assembly - http://en.wikipedia.org/wiki/Self-assembly
- Protein assembly - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15078223&dopt=Citation
- Self-assembly of peptides and proteins - http://web.mit.edu/newsoffice/2001/peptide-0912.html
DNA assembly / templating - http://nanotechweb.org/articles/journal/4/8/1/1
Digital cells - http://www.sciencenews.org/articles/20030426/bob11.asp
- Computer Circuits made of Genes - http://www.phschool.com/science/science_news/articles/digital_cells.html
- Insilico Biology (Economist) - http://www.oreillynet.com/pub/wlg/1026
- Biomimetic insilico devices - http://biosystems.ucsf.edu/Researc/RecentPapers/biomimetic2005.pdf
- Genetic circuits
  - Directed evolution of a genetic circuit - http://www.pnas.org/cgi/content/full/99/26/16587
  - Genetic Circuits and synthetic Ecosystems - http://www.che.caltech.edu/groups/fha/circuits.html
DNA computing - http://computer.howstuffworks.com/dna-computer.htm

Additional Web resources:

DNA Microarray Methodology - Flash Annimation - http://www.bio.davidson.edu/courses/genomics/chip/chip.html
MIT Self Assembly movies - http://hrst.mit.edu/hrs/materials/public/WhitesidesBoncheva/Boncheva_movies.htm
Template-Directed Protein Self-Assembly - http://www.princeton.edu/~pmi/REU/presentations/christina_b/
Virtual Library, Chemistry, Nano Technology and Self Assembly - http://www.liv.ac.uk/Chemistry/Links/selfassembly.html
Whatis.com definition of self-assembly - http://whatis.techtarget.com/definition/0,,sid9_gci516537,00.html
How Far Can We Push Chemical Self-Assembly? - http://www.sciencemag.org/cgi/content/full/309/5731/95
UCSD Systems Biology Group - http://gcrg.ucsd.edu/

Resources for this week:

Microarray Technology and Applications PPT Lecture
Nano-Bio-Info Technology (NBIT) PPT lecture
Synthetic Biology PPT lecture

Learning outcomes for this week:

What is nanobiotechnology and nano-bio convergence?
Why is biology an 'instance' of nanotechnology?
What is bioinformatics?
What are digital cells and insilico computing?
What is DNA computing? How does it work?